Margaret O James Selected Research

Investigational Drugs

11/2020	Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
1/2020	Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
1/2018	Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.
1/2018	Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
1/2016	Pharmacogenetic considerations with dichloroacetate dosing.
4/2015	Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
12/2013	Pharmacokinetics of oral dichloroacetate in dogs.
2/2012	Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
3/2008	Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

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Margaret O James Research Topics

Disease

9	Neoplasms (Cancer) 11/2020 - 02/2012
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 12/2013
4	Lactic Acidosis 01/2020 - 02/2012
3	Metabolic Diseases (Metabolic Disease) 01/2016 - 03/2008
2	Breast Neoplasms (Breast Cancer) 01/2017 - 09/2005
2	Liver Neoplasms (Liver Cancer) 01/2017 - 06/2016
1	Noncommunicable Diseases 01/2022
1	Mycoplasma Infections 04/2020
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2019
1	Urinary Tract Infections (Urinary Tract Infection) 01/2019
1	Body Weight (Weight, Body) 01/2018
1	Hepatocellular Carcinoma (Hepatoma) 06/2016
1	Pulmonary Arterial Hypertension 12/2013
1	Tyrosinemias (Tyrosinemia) 09/2004

Drug/Important Bio-Agent (IBA)

9	Investigational DrugsIBA 11/2020 - 03/2008
4	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2018 - 02/2012
3	Dichloroacetic AcidIBA 01/2020 - 02/2012
2	Pharmaceutical PreparationsIBA 01/2022 - 04/2020
2	AcidsIBA 01/2017 - 02/2012
2	Celecoxib (Celebrex)FDA Link 01/2017 - 09/2005
2	ChloridesIBA 06/2016 - 04/2015
2	Tyrosine (L-Tyrosine)FDA Link 02/2012 - 09/2004
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA 10/2019
1	nitroxolineIBA 01/2019
1	AntioxidantsIBA 01/2019
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2019
1	Glutathione (Reduced Glutathione)IBA 01/2018
1	CarcinogensIBA 01/2017
1	Estrogens (Estrogen)FDA Link 01/2017
1	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2017
1	Proteins (Proteins, Gene)FDA Link 06/2016
1	EnzymesIBA 06/2016
1	glyoxylic acid (glyoxylate)IBA 06/2016
1	Glyphosate (Roundup)IBA 01/2016
1	maleylacetoacetate isomeraseIBA 02/2012

Therapy/Procedure

2	Therapeutics 01/2018 - 06/2016